Fig. 1: Structure of α-LCT monomer.
From: Molecular architecture of black widow spider neurotoxins
a Domain organization of mature α-LCT. Gray diagonal lines indicate regions not resolved in the cryoEM density. b Representative reference-free two-dimensional class averages. Scale bar: 10 nm. c Side views of the α-LCT monomer superposed with the EM map (transparent) contoured at 10σ. Domains are depicted in the same colors as in (a). d Close-up view of the helical bundle domain. The front helix (H7) is not shown in the left image for clarity. e Close-up view of the interface between CD (H1-3) and ARD (AR5-10). f Close-up view of the ARD C-terminal tail. The gray ellipse indicates the last five ARs (AR14-18). Note the change in orientation g Electrostatic potential calculated in APBS. Red: −10 kT/e; Blue: +10 kT/e. PD:plug domain; HBD:helical bundle domain; CD: connector domain; ARD: ankyrin-like repeat domain.
