Fig. 1: In vivo shRNA screening for radiosensitizing targets. | Nature Communications

Fig. 1: In vivo shRNA screening for radiosensitizing targets.

From: Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Fig. 1

a & b RSA -log p-values (a) and median fold change (b) for each target in our two shRNA screening libraries for each tumor type tested. c & d RSA -log p-values in irradiated (XRT, y axis) versus untreated (x axis) for each tumor type tested (c) and the average for each group (d). Target genes in orange were selected for further analysis as potential radiosensitizers and analyzed for Gene Ontology term enrichment (e) (two-sided p-value presented).

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