Fig. 10: Proposed mechanism of CREBBP/EP300 mutant-specific radiosensitization. | Nature Communications

Fig. 10: Proposed mechanism of CREBBP/EP300 mutant-specific radiosensitization.

From: Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Fig. 10

Normal functioning of CBP and p300 shown on the left, with a potential gain of function (GOF) for both proteins shown on the right. The GOF mutation generally leads to increased protein acetylation, particularly BRCA1 acetylation, and increased DNA damage repair. Cells harboring these GOF mutations are sensitive to the combination of histone acetyltransferase (HAT) inhibition and radiation.

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