Fig. 3: Impaired HR and increased apoptosis is observed following CBP inhibition in CREBBP mutant cells. | Nature Communications

Fig. 3: Impaired HR and increased apoptosis is observed following CBP inhibition in CREBBP mutant cells.

From: Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Fig. 3

a, b TUNEL staining (a) and caspase-3 immunoblot (b) following irradiation in HNSCC cells expressing control or CREBBP shRNA. c ɣ-H2AX, 53BP1, and BRCA1 foci following irradiation in shControl or shCREBBP HNSCC cells. Significance tested via ANOVA with post hoc analysis adjusted for multiple comparisons. For a, c, a minimum of three independent samples for each condition are shown and are presented as mean values +/− SEM. For A, two-sided p-value shown for each indicated comparison. For c, (*) indicates a two-sided p < 0.05 for the comparisons shown.

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