Fig. 5: The HAT inhibitor A-485 radiosensitizes cells harboring CREBBP and EP300 mutations. | Nature Communications

Fig. 5: The HAT inhibitor A-485 radiosensitizes cells harboring CREBBP and EP300 mutations.

From: Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Fig. 5

a, b Clonogenic survival following irradiation and either A-485 (active) or A-486 (inactive) in CREBBP/EP300 mutant (a) or wild-type (b) HNSCC cells. c Surviving fraction at 4 Gy for each cell line (highest dose of A-485/A-486 shown). d, e TUNEL assay (d) and caspase 3 cleavage (e) in UM-SCC-47 (CREBBP mut), and HN5 (CREBBP/EP300 mut) and HN31 (CREBBP/EP300 wt) cells treated with radiation and either A-485 (active) or A-486 (inactive). For a–e, a minimum of three independent samples for each condition are shown and are presented as mean values +/− SEM with (*, #) -p < 0.05 vs. control (*) and A-486 (#). p-values are two-sided and derived from ANOVA with post hoc analysis adjusted for multiple comparisons.

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