Fig. 6: HAT inhibition primarily reduces HR and not NHEJ in CREBBP/EP300 mutant cells. | Nature Communications

Fig. 6: HAT inhibition primarily reduces HR and not NHEJ in CREBBP/EP300 mutant cells.

From: Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Fig. 6

a, b I-Scel assay for HR (a) and NHEJ (b) as described in the methods following treatment with A-485, A-486, or + control (ATMi or ATRi). A minimum of three independent samples for each condition are shown and are presented as mean values +/− SEM. p-values for each indicated comparison are two-sided and derived from ANOVA with post hoc analysis adjusted for multiple comparisons.

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