Fig. 9: Whole-exome sequencing identifies CREBBP/EP300 mutation significantly associated with outcome and treatment failure in several SCC cohorts. | Nature Communications

Fig. 9: Whole-exome sequencing identifies CREBBP/EP300 mutation significantly associated with outcome and treatment failure in several SCC cohorts.

From: Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Fig. 9

a Forrest plot of hazard ratios (HR) for overall survival (OS) for TCGA patients known to have received radiation therapy (n = 276 patients). b, c Forest plot of HR for OS (b) and locoregional recurrence (LRR) (c) in a subset of TCGA patients treated uniformly with surgery and radiation and known patterns of failure (n = 94 patients). d, e Kaplan–Meier curves for LRR in patients with either CASP8 (d) or CREBBP/EP300 (e) mutations. f Forest plot and KM curves for OS by CREBBP/EP300 mutation in lung and cervix SCC cohorts.

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