Fig. 8: Matr3 maintains chromatin structure and coordinates regulation of gene expression and differentiation. | Nature Communications

Fig. 8: Matr3 maintains chromatin structure and coordinates regulation of gene expression and differentiation.

From: Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture

Fig. 8

a Matr3 is required to organize chromosomal structure and maintain compartmentalization. The strength of interactions between the B compartments (green) became stronger whereas the contacts between the A-type domains (orange) were reduced in Matr3 KO cells. In the local chromatin compaction within the TADs indicated by the dashed circles, the intra-TAD contact frequency between compartment B were decreased while the interaction frequency between compartment A increased. b The region of the left dashed box is shown on the right. Matr3 interacts with CTCF and cohesin, and Matr3 loss destabilizes their binding to a subset of chromatin regions, which is necessary for proper gene regulation (e.g. Mbd1, marked in blue). The resulting altered chromatin structure resembles that of more differentiated cells and appears to accelerate cell maturation by modulating regulatory regions more accessible. Differentiation-specific erythroid genes are shown in red.

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