Fig. 1: RNA-seq reveals a lung-specific aging signature.
From: Molecular programs of fibrotic change in aging human lung
a Schematic of the lung aging cohort (LAC), a study of human lungs varying in age across the adult lifespan and profiled with multiple approaches. b Participant age plotted against increasing order of age. c Demographic features. d Heatmap of gene expression by bulk RNA-seq of the distal lung. Genes listed were significantly correlated with age in a generalized linear model adjusted for smoking and gender (FDR p ≤ 0.1 by DESeq2 two-sided likelihood ratio test). Z-scores represent within-gene relative expression across samples.
