Fig. 3: Association with epidemiological, clinical, and technical factors.

a The WID-OC-index versus age in control samples from the internal and external validation datasets. b ROC curves for women above and below 50 years of age. c The WID-OC-index versus a 28 SNP ovarian cancer polygenic risk score (PRS) in the internal validation dataset. d ROC curve corresponding to the PRS score. e The distribution of the WID-OC-index across different histological subtypes (endometrioid borderline, mucinous-clear cell cancer, carcinosarcoma, and serous cancer with no information on grade have been classified as “other cancers”). p-values were computed using a two-tailed Mann–Whitney test. For indicated significant difference, exact p-value = 0.013. f The distribution of the WID-OC-index across different cancer stages. p-values were computed using a two-tailed Mann–Whitney test. For indicated significant difference, exact p value = 0.0023. For box plots in e and f, the centre line of each box corresponds to the median. The lower and upper hinges correspond to the first and third quartiles. The upper whisker extends from the hinge to the largest value no further than 1.5 * IQR from the hinge (where IQR is the inter-quartile range). The lower whisker extends to the smallest value at most 1.5 * IQR of the hinge. Data beyond the end of the whiskers are plotted individually. Source data are provided as a Source Data file.