Table 1 Odds ratios corresponding to quartiles defined using the internal validation ovarian cancer dataset.
From: The DNA methylome of cervical cells can predict the presence of ovarian cancer
Quartile | Control (N = 297) | Internal validation ovarian cancer (N = 83) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) |
|---|---|---|---|---|
(−2.38, −0.57) | 75 | 3 | 1.00 (reference) | 1.00 (reference) |
(−0.57, −0.21) | 74 | 10 | 3.25 (0.93,15.68) | 2.38 (0.56, 12.99) |
(−0.21, 0.17) | 74 | 13 | 4.20 (1.27,19.79) | 3.65 (0.87, 19.42) |
(0.17, 2.21) | 74 | 57 | 18.20 (6.33,79.95) | 10.26 (2.89, 49.1) |
Quartile | Control (N = 225) | External validation ovarian cancer (N = 47) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) |
(−2.38, −0.57) | 59 | 2 | 1.00 (reference) | 1.00 (reference) |
(−0.57, −0.21) | 57 | 6 | 2.94 (0.62,22.94) | 4.88 (0.85, 41.76) |
(−0.21, 0.17) | 49 | 6 | 3.42 (0.72,26.71) | 4.57 (0.77, 40.12) |
(0.17, 2.21) | 60 | 33 | 14.99 (4.26,103.18) | 26.25 (5.89, 194.92) |
Quartile | Control (N = 297) | Endometrial cancer (N = 217) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) |
(−2.38, −0.57) | 75 | 4 | 1.00 (reference) | 1.00 (reference) |
(−0.57, −0.21) | 74 | 6 | 1.50 (0.4,6.32) | 0.72 (0.17, 3.26) |
(−0.21, 0.17) | 74 | 15 | 3.68 (1.25,13.77) | 0.92 (0.24, 3.92) |
(0.17, 2.21) | 74 | 192 | 46.44 (18.41,159.14) | 11.20 (3.91, 40.51) |
Quartile | Control (N = 297) | Breast cancer (N = 329) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) |
(−2.38, −0.57) | 75 | 28 | 1.00 (reference) | 1.00 (reference) |
(−0.57, −0.21) | 74 | 49 | 1.77 (1.01,3.14) | 1.50 (0.83, 2.76) |
(−0.21, 0.17) | 74 | 91 | 3.27 (1.94,5.64) | 2.30 (1.29, 4.14) |
(0.17, 2.21) | 74 | 161 | 5.78 (3.49,9.8) | 5.27 (2.91, 9.78) |
Quartile | Control (N = 114) | BRCA1 cases (N = 87) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) |
(−2.38, −0.57) | 41 | 12 | 1.00 (reference) | 1.00 (reference) |
(−0.57, −0.21) | 26 | 15 | 1.95 (0.79,4.95) | 1.66 (0.64, 4.31) |
(−0.21, 0.17) | 31 | 12 | 1.32 (0.51,3.39) | 1.20 (0.42, 3.4) |
(0.17, 2.21) | 16 | 18 | 3.76 (1.49,9.88) | 2.59 (0.84, 8.08) |
