Fig. 4: In vitro evaluation of mitochondrial damage by the synergism of CDT and photoacidification. | Nature Communications

Fig. 4: In vitro evaluation of mitochondrial damage by the synergism of CDT and photoacidification.

From: MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

Fig. 4

a TEM ultrathin sectioning images of mitochondrial integrity in different groups. M in images represents the mitochondria. b Mitochondrial membrane potential analysis of HeLa cells treated with different groups by using flow cytometry. c CLSM images of cyclophilin D (Cyp D) expression in HeLa cells with different groups. Green: mitochondria; Red: Cyp D. d Quantitative analysis of J-aggregate and J-monomer in various treatments. e The co-localization rate of nanoagents with mitochondria in different groups. f Quantitative analysis of intracellular ATP concentration in various treatments. Data in (d–f) were represented as mean values ± SD, n = 3 biologically independent samples in (d–f). A representative image of three biologically independent samples from each group is shown in (a–c). P values were calculated by using one-way ANOVA. in (e, f).

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