Fig. 6: In vivo biodistribution of MOF-based nanoagents. | Nature Communications

Fig. 6: In vivo biodistribution of MOF-based nanoagents.

From: MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

Fig. 6

a In vivo fluorescence imaging of biodistribution of MUP and FMUP in HeLa tumor-bearing mice over time. The color gradient represents the range from the minimum mean fluorescence intensity (540) to the maximum fluorescence intensity (4600). b The mean fluorescence intensity of tumors in the group of MUP and FMUP with elapsing time. c The tumor/liver fluorescence intensity ratios in the group of MUP and FMUP with elapsing time. d, e Ex vivo images of tumors and other main organs at 48 h postinjection and corresponding mean fluorescence intensity analysis in the group of MUP and FMUP. The color gradient represents the range from the minimum mean fluorescence intensity (810) to the maximum fluorescence intensity (3300). f Frozen section staining images of main organs and tumors in MUP group and FMUP group. Red: Cy 5-lablled MOFs. Blue: nuclei. g T2-MRI images of mice before and after injection and corresponding analysis of △T2 value in the group of MUP and FMUP. Red dotted circles indicate the tumors. Data in (b–d, g) were represented as mean values ± SD, n = 3 biologically independent samples in (b–d, g). A representative image of three biologically independent samples from each group is shown in (a, e, f, g). P values were calculated by the two-tailed Student’s t test in (b, d, g).

Back to article page