Fig. 5: Substrate scope of Pd-catalyzed asymmetric umpolung difluoroallylation of different hydrazones 1 with allyl reagent 2a. | Nature Communications

Fig. 5: Substrate scope of Pd-catalyzed asymmetric umpolung difluoroallylation of different hydrazones 1 with allyl reagent 2a.

From: Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand

Fig. 5

Reaction conditions: 1/LDA/2a/[Pd(C3H5)Cl]2/L8 = 200/200/100/2.5/5; 0.05 M of 2a; 3/4/5 ratio was determined by 19F NMR of crude products, trifluoromethylbenzene as the internal standard; yield was the isolated yields for 3; er value was determined by chiral HPLC. [a]Ran at 10 °C.

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