Fig. 6: SCN10A−/−/CaMKIIδc+/T exhibit less in vivo arrhythmias compared to CaMKIIδc+/T mice. | Nature Communications

Fig. 6: SCN10A−/−/CaMKIIδc+/T exhibit less in vivo arrhythmias compared to CaMKIIδc+/T mice.

From: Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure

Fig. 6

a Original ECG traces from telemetry recordings of 10-week-old CaMKIIδc+/T and SCN10A−/−/CaMKIIδc+/T mice showing ventricular arrhythmias. b Unchanged activity levels in SCN10A−/−/CaMKIIδc+/T compared to CaMKIIδc+/T (CaMKIIδc+/T (four mice); SCN10A−/−/CaMKIIδc+/T (three mice), four individual recordings each). Data were presented as mean values ± SEM, analyzed by unpaired two-tailed Student’s t-test. c Mean values of premature ventricular contractions (PVCs) in SCN10A−/−/CaMKIIδc+/T (p = 0.08, Unpaired two-tailed Student’s t-test), CaMKIIδc+/T (four mice); SCN10A−/−/CaMKIIδc+/T (three mice), four individual recordings each. Data were presented as mean values ± SEM. d Reduction of ventricular tachycardia (VT) incidence in SCN10A−/−/CaMKIIδc+/T (p < 0.05, Unpaired two-tailed Student’s t-test), CaMKIIδc+/T (four mice); SCN10A−/−/CaMKIIδc+/T (three mice), four individual recordings each. Data were presented as mean values ± SEM.

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