Fig. 1: Overall structures of the GHSR-Gi complexes.
From: Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
a, b Cryo-EM density maps of the complex with ghrelin (orange) and ibutamoren (yellow) and overall structures. GHSR bound to ghrelin and ibutamoren is colored in blue and green, respectively. Gαi, Gβ, and Gγ subunits are colored in cyan, pink, and light blue, respectively. ScFv16 is colored in gray. The density maps of the two agonists are shown in light gray. The octanoyl group in ghrelin is circled.
