Fig. 3: DUSP1 homology model showing (a) the wild-type protein, (b) the mutated protein.
From: Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
Eczema-associated variants change the amino acids (in pink) at positions 56 (alanine, Ala, to threonine, Thr) and 187 (tyrosine, Tyr, to histidine, His). The kinase-interacting motif (blue), the phosphotyrosine-binding loop (green), and Asp227 (light blue) which belongs to the catalytic site are indicated. Acid and base groups in the functional sites are marked red and blue respectively.
