Fig. 4: Distribution of HBV insertions across the HCC genome and association with genomic organisation features. | Nature Communications

Fig. 4: Distribution of HBV insertions across the HCC genome and association with genomic organisation features.

From: Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

Fig. 4

a Bars show the number of HBV insertions per 10-Mb window of the genome. Red bar represents the TERT hotspot at chromosome 5p. Other genes (KMT2B and CCNE1) with high rate of HBV insertion are shown at chromosome 19q. b HBV insertions are more frequent in genes than expected by chance (χ2 test, P = 0.0035, n = 91) and depleted in intergenic regions of the genome (χ2 test, P = 0.035, n = 55). False Discovery Rate “FDR” correction was applied (see Methods). c HBV events at telomeric deletion breakpoints are depleted in regions of the genome exhibiting early replication timing (χ2 test, P = 0.037, n = 4), while the remaining HBV insertions show the opposite pattern (χ2 test, P = 0.013, n = 34). “ns” stands for not significant. FDR correction was applied.

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