Fig. 4: Substantial T cell receptor (TCR) repertoire intratumor heterogeneity (ITH) in small-cell lung cancer (SCLC). | Nature Communications

Fig. 4: Substantial T cell receptor (TCR) repertoire intratumor heterogeneity (ITH) in small-cell lung cancer (SCLC).

From: Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer

Fig. 4

a Quantification of TCR ITH by Jaccard index (JI), a metric representing the proportion of shared T-cell clonotypes between two samples in 10 SCLC patients with multiregion TCR sequencing data. b Proportions of T-cell clonotypes detected in all regions (shared, blue), in 2/3 (brown) and restricted to a single region (red) from the same tumors in 10 SCLC patients with multiregion TCR sequencing data. Patient ID: purple = alive; green = deceased. Source data are provided as a Source Data file.

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