Fig. 10: PQBP1 depletion in microglia recovers memory functions impaired by Tau.
From: Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
a Memory dysfunction after injection of various species of tau in non-polymerized or polymerized state was evaluated by Y-maze test and Morris water maze test. Protocol from injection to memory function tests in various conditions is shown in Fig. 6a. Y-maze test: N number in each group is indicated in Source data. In Morris water maze test, values in each group are presented as mean ± SEM; N = 6 mice/group. #P < 0.05, ##P < 0.01, ###P < 0.001 in Dunnett’s test. Box plots show the median, quartiles. and whiskers that represent data outside the 25th to 75th percentile range. b PQBP1-depndent and PQBP1-independent pathways mediating microglia activation to neuronal cell death or neuronal cell death to microglia activation. Different types of tau species trigger distinct pathways.
