Fig. 2: Delineation of SARS-CoV-2 NP-positive cells and total viral burden from postmortem biopsies, by tissue type.
From: Organ-specific genome diversity of replication-competent SARS-CoV-2
A total of 516 SARS-CoV-2 nucleocapsid protein (NP)-positive cells were evaluated for marker expression (123 for ACE2, 133 for cytokeratin [CK], 136 for CD14, and 120 for ICAM) across different organs of three cases with viral dissemination (case 06, 07, and 13). The first level of the sunburst chart represents the distribution of SARS-CoV-2 NP-positive cells across different organs (blue = lung, red = heart, brown = liver, green = kidney, purple = spleen). The second level of the sunburst chart depicts the percentage of cell types positive for SARS-CoV-2 NP per organ (forward slash = cytokeratin [CK], backward slash = CD14, crosshatch = ICAM, dotted = not identified [NI]), and the third level shows co-localization data with ACE2 (long and short form). Source data are provided as a Source Data file. Representative confocal images are grouped per organ (different colors) at the outer edges. Scale bars represent 25 µm.
