Fig. 2: Interactions of NSD2 with histones H3 and H2A and DNA.

The cryo-EM density is shown as a blue mesh in a (contoured at 7σ), b (at 3σ), and d (at 5σ). a Interactions with the first α-helix of H3 and DNA. b Interactions with H2A. c Interactions with the H3 tail region. d The H3K36-binding cavity.