Fig. 3: Associations between individual low-dimensional trajectories of brain activity and working memory performance.

a Analysis of the total length of low-dimensional trajectories for correct 2-back trials (measured across PHATE1, PHATE2, and PHATE3 dimensions) revealed a gradient linking individual trajectory length and behavioral accuracy across experimental sessions. Here each participant is tiered by overall task accuracy bands (% of correct 2-back trials). b Linear relationship between participants’ trajectories and task accuracy for each session. In the baseline and the S1 session, longer trajectories link to higher 2-back accuracy whereas following perturbation of iPS, longer trajectories corresponded with lower task accuracy. Source data are provided as a Source data file.