Fig. 3: G3BP1 overexpression is associated with aggressive PCa and correlated with increased accumulation of AR and TRIM24.
From: G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer
a Stepwise upregulation of G3BP1 mRNA levels with increasing tumor group grade in the TCGA cohort patients15. Unpaired t-test. In box plots, the center line represents median value, box limits represent 25% and 75% quantiles, and the top and bottom lines represent minimal and maximal values, respectively. b Kaplan–Meier metastasis-free survival analysis of PCa patients. Patients were stratified as low and high G3BP1 expression (log rank test, p = 0.0003). PCa patients undergoing radical prostatectomy and reaching metastasis postoperatively were used for analysis37. c Expression of G3BP1 in benign (n = 128), primary PCa tumors (Tumor) (n = 153), and CRPC (n = 15). The scale bar represents 50 µm. Paired t-test. p value is indicated in figure. d, e Correlation of G3BP1 protein and nuclear staining of AR (d) and TRIM24 (e). Paired t-test. The scale bar represents 50 µm. For c–e, 60 benign prostate tissues, 73 localized prostate cancers, and 16 metastatic castration-resistant prostate cancer tissues were used.
