Fig. 8: Model for HPF1 regulation of PARP1/2 catalytic output. | Nature Communications

Fig. 8: Model for HPF1 regulation of PARP1/2 catalytic output.

From: HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

Fig. 8

HPF1 regulates the balance between initiation (i) and elongation (e) through a dynamic interaction with the catalytic domain and by accelerating the rate of initiation on Ser residues. Rapid HPF1 cycling between PARP1 molecules, indicated by the long arrow, allows the PARP1 population to be efficiently modified on Ser, and also prevents excessive inhibition of the elongation reaction to form PAR that is important for DNA damage signaling.

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