Fig. 6: Fluoxetine rescues depression-like behaviors and ADRB2/c-MYC/SIRT1 protein expression induced by hippocampal FTO deficiency. | Nature Communications

Fig. 6: Fluoxetine rescues depression-like behaviors and ADRB2/c-MYC/SIRT1 protein expression induced by hippocampal FTO deficiency.

From: Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

Fig. 6

a Schematics of the experimental design. b, c FST and NSFT after treatment with fluoxetine. EGFP-Saline, n = 13; cKO-Saline, n = 11; cKO+Fluoxetine, n = 13; EGFP- Fluoxetine, n = 14. b EGFP-Saline vs. cKO-Saline, p < 0.0001; cKO-Saline vs. Cko+Fluoxetine, p = 0.0001. c EGFP-Saline vs. cKO-Saline, p = 0.0187; cKO-Saline vs. Cko+Fluoxetine, p = 0.0011. d, e SIRT1, ADRB2 and c-MYC expression in the hippocampus of Fto-cKO mice treated with fluoxetine, n = 3 per group. d ADRB2, EGFP-Saline vs. cKO-Saline, p = 0.0481; cKO-Saline vs. cKO+Fluoxetine, p = 0.0008. SIRT1, EGFP-Saline vs. cKO-Saline, p = 0.0028; cKO-Saline vs. cKO+Fluoxetine, p = 0.0239. e EGFP-Saline vs. cKO-Saline, p = 0.0021; cKO-Saline vs. cKO+Fluoxetine, p = 0.0016. *p < 0.05, **p < 0.01, ***p < 0.001. Statistical significance was calculated using one-way ANOVA and adjustments were made for multiple comparisons test. Source data are provided as a Source Data file.

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