Fig. 5: Immunological phenotype of mice carrying the PSMB9 G156D mutation. | Nature Communications

Fig. 5: Immunological phenotype of mice carrying the PSMB9 G156D mutation.

From: Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency

Fig. 5

a A photograph and histological images of the thymus. Scale bars in the leftmost and the other two panels represent 5 mm and 500 μm, respectively. Representative images from three mice were shown. b Cryosections of the spleen stained with hematoxylin and eosin (HE, left panel), anti-B220 Ab (middle panel), or anti-Thy1.2 Ab (right panel). Scale bars,500 μm. Representative images from three individual mice were shown. c Serum immunoglobulin levels. n = 6 in each group. Statistical analysis was performed with two-sided Welch’s t-test. d FACS analysis of B and T cells, DCs, and NK cells, in the spleen or bone marrow. The numbers represent the percentages of the cells within the indicated gates or each quadrant among splenocytes or bone marrow cells. e FACS analysis of neutrophils and monocytes in the spleen. The left and right panels show FcεRI− DX5− Siglec-F− and FcεRI− DX5− Siglec-F− Ly6G− cells, respectively. The numbers represent the percentages of neutrophils and monocytes among splenocytes.

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