Fig. 2: Investigation of reaction substrate scope with respect to the alkenes and Katritzky salts.
From: Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
Reaction condition A: alkene (0.2 mmol), Katritzky salt (0.5 mmol, 2.5 equiv), Et3N (0.4 mmol, 2.0 equiv), K2CO3 (0.2 mmol, 1.0 equiv), and H2O (6.0 mmol. 30 equiv) in CH3CN (3.0 mL), violet LED (24 W, 410-420 nm), argon atmosphere, 12 h, room temperature. Reaction condition B: alkene (0.2 mmol), Katritzky salt (0.4 mmol, 2.0 equiv), PPh3 (0.48 mmol, 2.4 equiv), KOCH3 (0.6 mmol, 3.0 equiv), and H2O (5.0 mmol. 25 equiv) in acetone (3.0 mL), violet LED (24 W, 420–430 nm), argon atmosphere, 12 h, room temperature. Isolated yields after chromatographic purification. aRegio- or diastereomers were measured by1H NMR. bDiastereomers were measured by HPLC. a Substrates with alkenes (Condition A and B). b Substrates with Katritzky salts (Condition A and Condition B).
