Table 1 Control experiments.
From: Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
| ||
|---|---|---|
Entry | Changes from condition A or B | Yield of 5a (%)a |
1 | no change from condition A | 97% (94%) |
2 | no change from condition B | 88% (84%) |
3 | no K2CO3 under condition A | 50% |
4 | no KOCH3 under condition B | 13% |
5 | KF instead of K2CO3 under condition A | 63% |
6 | CsF instead of KOCH3 under condition B | 41% |
7 | without Et3N or PPh3 | trace |
8 | without H2O | <54% |
9 | no light | N.D. |
10 | no light, 60 oC | N.D. |
