Fig. 8: Firing activity in PFC during light-induced activation of LEC terminals in HP. | Nature Communications

Fig. 8: Firing activity in PFC during light-induced activation of LEC terminals in HP.

From: Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice

Fig. 8

a Schematic of AAV9-CaMKII-ChR2-mCherry injection in LEC and light stimulation of entorhinal axonal terminals in HP. b Line plot of firing activity of prelimbic layer 5/6 neurons during 3 s-long ramp stimulation (light blue shadow) of LEC terminals in HP normalized to the activity before stimulation for CON and GE mice. The horizontal dotted line corresponds to no changes of firing activity during the stimulation. Right, violin plots displaying the firing activity of prelimbic layer 5/6 neurons during 3 s-long ramp stimulation normalized to the activity before stimulation (Wilcoxon rank-sum test, p = 0.0010, zval = 3.28, ranksum = 250). c Same as b for prelimbic layer 2/3 neurons (Wilcoxon rank-sum test, p=0.04, zval=2.083, ranksum=221). (d) Line plots of HP-PFC coherence calculated during ramp stimulation of entorhinal terminals in HP and normalized to coherence values before stimulation. Inset, violin plot displaying the averaged 12–20 Hz coherence between HP and PFC during stimulation when normalized to coherence values before stimulation (one-way ANOVA, p = 0.03, F(1, 25) = 5.18). For violin plots, black and red dots correspond to individual animals and the red horizontal lines display the median as well as 25th and 75th percentiles. *p < 0.05, **p < 0.01.

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