Fig. 1: Overview of the NeDRex platform.
From: Network medicine for disease module identification and drug repurposing with the NeDRex platform
a Integration of various biomedical databases. b Construction of heterogeneous networks. c Disease module identification using network-based algorithms (MuST, DIAMOnD, BiCoN). d Ranking of drugs using network-based algorithms (TrustRank, closeness centrality). Benefiting from the expert-in-the-loop paradigm, expert knowledge can be engaged at two points: (1) before the disease module identification step through selecting seeds; (2) before the drug ranking step through selecting seeds for ranking algorithms. e Statistical validation of the obtained disease modules and ranked lists of drugs via empirical P values. X-axis: Concordance of contained drugs (for drug list validation) or targeting drugs (for disease module validation) with list of reference (e.g., indicated) drugs. Created with BioRender.com.
