Table 1 Overview of the main functionalities of the NeDRex platform.
From: Network medicine for disease module identification and drug repurposing with the NeDRex platform
Functionality | Description |
|---|---|
Integrating data from multiple biomedical databases | NeDRexDB is an integrated knowledgebase which is accessible via NeDRexAPI as well as a Neo4j endpoint. |
Constructing heterogeneous biological networks from NeDRexDB | Based on users’ needs, different heterogeneous networks can be constructed using NeDRexAPI or NeDRexApp. |
Disease module mining | Various disease module identification algorithms can be run on NeDRexDB using NeDRexApp or NeDRexAPI, based on users’ inputs. |
Drug prioritization | Various drug prioritization algorithms can be run on NeDRexDB using NeDRexApp or NeDRexAPI, based on users’ inputs and the results of disease module mining. |
Statistical validation of results | The results of disease module identification and drug prioritization analyses can be validated with different statistical methods. |
Visualization of results | Using NeDRexApp, all the obtained results are shown in network format, which can be explored further. |
