Fig. 7: Defining the stage-specific erythroid regulatory networks.
From: Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation
a Representative top differentially expressed TF genes between populations as identified by Wilcoxon sum rank test. b Schematic diagram of the regulatory network construction logic. Differentially expressed TFs among single-cell populations are assigned to their target genes based on elastic-net regression results. DHSs are linked to their target genes using correlation between population level DHS density and gene expression. c Regulatory networks initiated by TFs specific to each population. Up to top 50 target genes are shown for each TF. Transcription factors and select marker genes are annotated.
