Fig. 5: Conserved pulmonary cellular connectomes.

a Communication network of receptor–ligand pairs between lung cell types of indicated species. Cell type was represented by colored node, of which the size was directly proportional to sum of receptor–ligand pairs between this node and all other nodes. Edge width was directly proportional to number of receptor–ligand pairs between two connected nodes. b Plot (upper) showing source weight and hub score of various cell types in indicated nine species. Plot (lower) showing target weight and authority score of nine cell types. c Comparison of degree rankings and the effect of thresholding of lung cell types in indicated species. The x-axis (“percent.source”) is percent of cell type expressing the marker, and the y-axis is the degree of each node plotted on a logarithmic scale. d Plot showing source weight of VEGF signaling family in nine cell types. e Violin plots showing expression level of indicated ligand and receptor genes within each cell type of lung in different species. f Circos plot of mammalian-specific conserved connectome in cat. Receptors and ligands were displayed near the upper and lower half circle, respectively.