Fig. 6: Conservation of regulomes in pulmonary cells.
From: Single cell atlas for 11 non-model mammals, reptiles and birds
a Genetic regulatory network constructed with top 30 TFs with largest number of interactions and predicted target genes in AT1 cells, ciliated cells, and macrophages. b Highly conserved genetic regulatory networks in AT1 cells within each indicated species. Light blue nodes represent regulators, green nodes represent corresponding target genes. Edge width is proportional to weight of regulation and node size is proportional to number of target genes of regulator. c GO enrichment related to cellular functions of predicted target genes of top 30 TFs in AT1 cells, ciliated cells, and macrophages, respectively. Dot color represents significance level of enrichment analysis and dot size is count of target genes classified in GO terms. P-values were calculated using hypergeometric test. Multiple comparisons adjustment was performed using Benjamini and Hochberg method. Exact P-value and source data were included in the Source Data file.
