Fig. 1: Development of small molecule dimerizing systems. | Nature Communications

Fig. 1: Development of small molecule dimerizing systems.

From: Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices

Fig. 1

a Graphic representation of a dimerizing system that relies on formation of a new interface including an anchor protein and small molecule. The second binder recognizes this interface in a ligand-dependent way. b Dimerizing system where ligand binding leads to a conformation change of the anchor domain that is recognized by the second binder. c Ribbon representation of dihydrofolate reductase:methotrexate complex (PDB:1DDS). d thymidylate synthase:methotrexate complex (PDB:1AXW). e VHH: methotrexate complex (PDB:3QXV) displayed as white ribbon. Methotrexate is displayed in ball and stick representation with atomic colors.

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