Fig. 7: Loss of TAOK2 directly impacts IFN-α/β secretion. | Nature Communications

Fig. 7: Loss of TAOK2 directly impacts IFN-α/β secretion.

From: Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

Fig. 7

a–g THP-1 control (green) or TAOK2 KO (blue) cells were infected with SFV at the indicated MOI and 24 h later the accumulation of cytokines in the supernatant was measured by ELISA (IFN-β (a) and IP-10 (b)) and cytometric bead array (MCP-1/CCL2 (c), MIP-1b/CCL4 (d), TNF (e), IL-6 (f), and IL-8 (g)). Data presented is averaged across four biological repeats with mean ± SD. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, ns p > 0.05 (Two-way ANOVA with Šídák’s multiple comparison test). Source data are provided as a Source Data file.

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