Fig. 9: Summary of screening results. | Nature Communications

Fig. 9: Summary of screening results.

From: Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

Fig. 9

a Overlap of proteins between human (brown) and fly (green; combined results from drosophila and S2 cells), which were identified as NA binder in the AP-MS screen (LC–MS/MS), selected as candidates for further functional validation (Candidates) and that showed an anti- or proviral phenotype upon depletion (Functional screening). Orthologue mapping between human and fly proteins was performed using DRSC Integrative Ortholog Prediction Tool. b Overview of the results gathered in the screening approaches in humans and fly for the 28 top candidates (red: antiviral, green: proviral). Shown are human proteins with annotated orthologues in fly. *for ILF3 we observed an increase of viral replication in PMA treated THP-1 cells, but a decrease of viral replication in the untreated THP-1 cells.

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