Fig. 6: Mouse mutant IL7R leukemias resemble Ph-like and PAX5 P80R human B-ALL. | Nature Communications

Fig. 6: Mouse mutant IL7R leukemias resemble Ph-like and PAX5 P80R human B-ALL.

From: Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

Fig. 6

a Principal component analysis (PCA) plot of gene expression profiles from mouse leukemia samples. b Mutational burden map of copy number variants (CNVs), single nucleotide variants (SNVs), and indel variants with predicted high and moderate impact in genes of interest. c Heatmap of PAM posterior probabilities classification of human Ph-like samples (from ref. 16) into the two apparent Ph-like subgroups observed in IL7R mutant leukemic mice. d Oncogenes and tumor suppressor genes significantly (adj. p < 0.05; moderate t-test) up- and downregulated, respectively, in leukemic samples as compared to controls. Log2 fold-changes (FC) are indicated for each gene. Source data are provided as a Source Data file.

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