Fig. 6: Whole genome bisulfite sequencing and ATAC-sequencing data of kidney tissue at SLC2A9. | Nature Communications

Fig. 6: Whole genome bisulfite sequencing and ATAC-sequencing data of kidney tissue at SLC2A9.

From: Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

Fig. 6

Whole genome bisulfite sequencing of kidney samples (n = 5) showed that lower DNA methylation levels at CpGs localized to the promoter-associated region in isoform 1 on SLC2A9 and aligned with gene expression levels from RNA-sequencing (A). ATAC-sequencing data from primary human kidney tissue (n = 3 from micro-dissected cortex and medulla each) showed that the three promoter-associated CpGs, and—to a lesser extent cg20479063—mapped to DNA sequences with high chromatin accessibility in the kidney (B). Gene models were based on Genbank RefSeq (accession numbers: isoform 1, NM_020041; isoform 2, NM_001001290).

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