Fig. 4: Tuning transient asymmetry by enzyme density varies motion dynamics.
From: Engineering transient dynamics of artificial cells by stochastic distribution of enzymes
a Schematic illustration of coacervates with different enzyme densities (low, medium, and high) leading to different organizational states. b The distribution of the number of enzymes per coacervate is presented per density based on 100,000 simulated functionalized particles of each density (λlow = 100, λmedium = 300, λhigh = 1000). The asymmetry was computed as the net propulsion in the \(({{{\boldsymbol{x}}}},{{{\boldsymbol{y}}}})\)-plane divided by the number of enzymes (as vc = µm/s in these simulations) per coacervate. c, e MSD curves of mCAT-coacervates/mUR-coacervates (diameter ~ 1.2 µm) with three different enzyme densities, namely, low, medium, and high (Supplementary Table 2). The MSD curves with error bars (mean ± SEM) are available in Supplementary Fig. 10. Inset is the corresponding velocity. Eighteen coacervates were analyzed per condition for mCAT-coacervates and 17 coacervates were analyzed per condition for mUR-coacervates. d, f MSD curves of mCAT-coacervates/mUR-coacervates predicted by stochastic simulation.
