Fig. 1: EWAS results of eGFR and UACR.
From: Meta-analyses identify DNA methylation associated with kidney function and damage
Chicago plots of the epigenome-wide association study (EWAS) results for estimated glomerular filtration rate (eGFR) (A) and urinary albumin-to-creatinine ratio (UACR) (B) using the combined discovery and replication sample. The sites are ordered by their chromosomal position on the x-axis, with their –log10 P-value of the association Wald-test provided on the y-axis. CpGs positively correlated with the trait are plotted in the upper part, sites with negative correlation in the lower part. The dotted horizontal lines represent the level of significance (P-value < 1.1E−7). Novel replicates sites are colored in orange, known replicated sites are colored in turquois, and sites that were additionally associated with the respective binary trait (chronic kidney disease [CKD]/ microalbuminuria [MA]) are marked with a cross.
