Fig. 2: Similar effects between EA and AA-specific analyses.
From: Meta-analyses identify DNA methylation associated with kidney function and damage
Comparison of effect estimates of the association Wald-test of the significantly associated CpG sites (CpGs) for estimated glomerular filtration rate (eGFR) (A) and urinary albumin-to-creatinine ratio (UACR) (B). The effects in the European ancestry (EA) meta-analysis epigenome-wide association study (x-axis) (neGFR = 23,671; nUACR = 9806) are compared with the corresponding effect sizes of the African American ancestry (AA) subsample (y-axis) (neGFR = 5019; nUACR = 1921). In panel (A), sites that showed a significant P-value of the two-sided t-test for ancestry heterogeneity (P-value < 0.05/69) are colored in blue and labeled with the closest gene name. In all panels, the dashed gray line represents the linear regression slope between the dots, the solid gray line shows the diagonal, error bars indicate 95% CIs, and the Pearson correlation coefficient r between the effect estimates is shown.
