Fig. 3: Effects of eGFR-associated sites on CKD and of UACR-associated sites on Microalbuminuria.
From: Meta-analyses identify DNA methylation associated with kidney function and damage
Comparison of effect estimates of the association Wald-test of the significantly associated CpG sites for estimated glomerular filtration rate (eGFR) (n = 33,605) (A) and urinary albumin-to-creatinine ratio (UACR) (n = 15,068) (B). The effects in the combined epigenome-wide association study (x-axis) are compared with the corresponding effect sizes (odds ratio) for chronic kidney disease (CKD) (n = 25,609) and microalbuminuria (n = 7279), respectively (y-axis). In panel (A), sites that were not nominally significantly associated with CKD (association test P-value≥0.05) are colored in blue and labeled with the closest gene name. In all panels, the dashed line represents the linear regression slope between the dots, error bars indicate 95% CIs, and the Pearson correlation coefficient r between the effect estimates is shown.
