Fig. 4: Enrichment in transcription factor binding sites and histone marks.
From: Meta-analyses identify DNA methylation associated with kidney function and damage
Enrichment analysis of CpG sites (CpGs) significantly associated with estimated glomerular filtration rate (eGFR) (A) and urinary albumin-to-creatinine ratio (UACR) (B) for mapping into regions containing specific transcription factor binding sites at Benjamini-Hochberg FDR < 0.05. Panels (C) and (D) show the corresponding results for mapping into histone marks. In these panels, the Y-axis show the −log10(P-value) from a binomial test comparing the expected and observed numbers of significant CpGs that map into the binding site regions for a given target. On the X-axis, the results with an FDR < 0.05 of 169 evaluated transcription factors are listed in alphabetical order. Enrichment testing was carried out using permutation with matching for genomic localization when sampling from the background.
