Table 1 Pooled characteristics of the discovery and replication samples.
From: Meta-analyses identify DNA methylation associated with kidney function and damage
EWAS Trait | eGFR | UACR | ||
|---|---|---|---|---|
EWAS stage | Discovery | Replication | Discovery | Replication |
Ancestries included | AA, EA, HIS, SA, SSA | AA, EA | AA, EA, HIS, SSA | AA, EA, AI |
Sample sizea | 22,318 | 11,359 | 11,579 | 3611 |
Age, mean (SD) | 56.8 (12.5) | 56.0 (15.7) | 59.2 (12.2) | 58.0 (10.6) |
Male, % (n) | 48.6 (10855) | 44.6 (5071) | 47.3 (5472) | 42.9 (1550) |
Diabetes, % (n) | 12.6 (2813) | 8.3 (948) | 12.9 (1492) | 32.5 (1175) |
Hypertension, % (n) | 44.3 (9888) | 48.2 (5480) | 49.5 (5729) | 49.0 (1770) |
BMI (kg/m2), mean (SD) | 27.8 (5.2) | 27.6 (5.7) | 28.2 (5.3) | 30.3 (6.3) |
Current smoking, % (n) | 14.5 (3236) | 16.1 (1832) | 13.3 (1538) | 28.6 (1032) |
eGFR, mean (SD), mL/min/1.73m2 | 87.4 (19.4) | 91.2 (20.3) | 86.4 (19.5) | 93.9 (19.1) |
UACR, median (1st, 3rd quartile), mg/g | NA | NA | 6.5 (4.0, 12.3) | 7.7 (3.8, 20.3) |
CKD, % (n) | 7.8 (1741) | 7.4 (842) | NA | NA |
microalbuminuria, % (n) | NA | NA | 10.4 (1207) | 18.4 (666) |
