Table 3 CpG sites having a potentially causal effect on eGFR as assessed by Mendelian randomization.

From: Meta-analyses identify DNA methylation associated with kidney function and damage

probeID

N instruments

Effect size

Standard error

P-value (Wald-test)

FDR

Nearest gene

cg02304370

6

4.22E−03

1.09E−03

1.11E−04

0.004

PHRF1

cg04460609

7

2.61E−03

7.63E−04

6.25E−04

0.015

LDB2

cg00501876

3

9.92E−03

3.00E−03

9.45E−04

0.019

CSRNP1

cg04864179

21

3.13E−03

9.62E−04

1.12E−03

0.020

IRF5

  1. Results of the inverse-variance weighted Mendelian randomization of the DNA methylation on estimated glomerular filtration rate (eGFR) levels. The effect estimates provide the per-unit change in one standard deviation of DNA methylation levels on natural log-transformed eGFR. FDR: false discovery rate.
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