Fig. 10: Pharmacological activation of STAT3 activity promoted osteoblast differentiation and partially prevented bone mass loss induced by tail suspension by promoting osteogenesis.
From: STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis
a Micro-CT images of distal femurs from 5-week-old Vehicle, TS + Vehicle, and TS + Colivelin group mice. Four-week-old male mice were used to perform the tail suspension model with or without 1 mg/kg colivelin every day for 1 week. b–f Quantitative parameters of micro-CT, including BV/TV, Tb.Th., Tb.N., Tb.Sp., and Ct.Th. n = 5. g Images of calcein-alizarin red S double labeling of femurs from 5-week-old Vehicle, TS + Vehicle, and TS + Colivelin group mice and quantitative parameters of MAR. n = 5. Two-tailed Student’s t test. Data represent the mean ± s.d. Source data are provided in the Source data file.
