Fig. 2: Extracellular Ca2+ binding sites in TTYH2. | Nature Communications

Fig. 2: Extracellular Ca2+ binding sites in TTYH2.

From: Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization

Fig. 2

a, b View from the membrane plane of the TTYH2 cis-dimer model (purples) and cryo-EM density (blue mesh). Electronegative side chains from each protomer are displayed as sticks and Ca2+ ions are shown as green spheres. c Alignment of mouse TTYHs with electronegative residues near the Ca2+ binding sites indicated with green boxes and conservation colored from white (not conserved) to blue (most conserved).

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