Fig. 8: Model of Arm-Smc5/Nse2 interaction with E2-SUMOD thioester and SUMOB backside.
From: Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs
DNA associates with Smc5 leading to conformational changes of Nse2 SIM1 and SIM2 which clamps E2~SUMO thioester and SUMO backside into the closed and active conformation.
